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Posted by JaclinHyde on March 31, 2006, at 14:52:06

I did a medscape check on the interactions of all your meds and this is what came up....

"Patient Regimen



Contraindicated Drug Combination
Benadryl Oral and Parnate Oral may interact based on the potential interaction between SELECTED SYMPATHOMIMETICS and MAOI'S.

Selected Sympathomimetics/MAOI's

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

MONOGRAPH TITLE: Selected Sympathomimetics/MAOI's

SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient.

MECHANISM OF ACTION: Catecholamine stores increased by MAOIs can be released by indirect acting sympathomimetics such as ephedrine and amphetamine. MAO inhibitors also interfere with gut and liver metabolism of direct acting sympathomimetics (eg oral phenylephrine).

CLINICAL EFFECTS: Potentiation of sympathomimetic effect may be observed. FATALITIES HAVE OCCURED. PREDISPOSING FACTORS: None determined.

PATIENT MANAGEMENT: Concurrent use of monoamine oxidase inhibitors and sympathomimetics is contraindicated.

DISCUSSION: Indirect acting sympathomimetic amines may cause abrupt elevation of blood pressure when administered to patients taking monoamine oxidase inhibitors, resulting in a potentially fatal hypertensive crisis.

Mixed (direct and indirect) acting sympathomimetics have also been shown to interact with monoamine oxidase inhibitors depending on their degree of indirect action. The direct-acting sympathomimetics have not been reported to interact. Dopamine is metabolized by monoamine oxidase, and its pressor effect is enhanced by monoamine oxidase inhibitors.

Since procarbazine, an antineoplastic agent, is a weak monoamine oxidase inhibitor, hypertensive reactions may result from its concurrent use with indirect and mixed acting sympathomimetics.

Furazolidone, an antibacterial with monoamine oxidase inhibitor action, has also been shown to interact with indirect acting sympathomimetics.

Linezolid is another antibacterial with monoamine oxidase inhibitor properties.

Foods containing large amounts of tyramine have also been implicated in this interaction.


1.Goldberg LI. Monoamine oxidase inhibitors. Adverse reactions and possible mechanisms. JAMA 1964 Nov 2;190(5):456-62.

2.Pettinger WA, Soyangco FG, Oates JA. Inhibition of monoamine oxidase in man by furazolidone. Clin Pharmacol Ther 1968 Jul-Aug;9(4):442-7.

3.Nardil (phenelzine sulfate) US prescribing information. Parke-Davis January, 2005.

4.Adderall (amphetamine) US prescribing information. Shire US Inc. June, 2005.

5.Marplan (isocarboxazid) US prescribing information. Oxford Pharmaceutical Services, Inc. January, 2002.

6.Ritalin (methylphenidate hydrochloride) US prescribing information. Novartis January, 2001.

7.Focalin XR (dexmethylphenidate hydrochloride) US prescribing information. Novartis Pharmaceuticals Corporation May, 2005."

Can you say "I'd rather sneeze than die"? I did a check on Claritin and Zyrtec and both were fine with everything you are taking. Sp PLEASE switch to one of this for your allergies and cut out the big "B". I'd miss you buddy.

This one is on me, no payment required ;-)

Parnate Protector




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