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Re: Any stimulant less likely to raise blood pressure? Racer

Posted by Chairman_MAO on March 10, 2006, at 12:22:09

In reply to Any stimulant less likely to raise blood pressure?, posted by Racer on March 9, 2006, at 20:04:26

Pemoline has the least cardiovascular toxicity of any (marketed psychostimulant). However, I believe it has been or will be withdrawn due to concerns over hepatotoxicity.

In second place is d-methamphetamine (Desoxyn), which has a much higher therapeutic index, i.e. the dose required for a CNS effect vis a vis the dose causing untoward effects or toxicity, than d-amphetamine or methylphenidate. This is due largely due to markedly higher lipid solubility.




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