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Re: Selegiline/Deprenyl effective anti-depressant? gibber

Posted by LizinManhattan on February 9, 2006, at 14:38:47

In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by gibber on February 8, 2006, at 23:13:36

Do you know which journal the study's in? I'd love to read the whole article, and have it for my doctor if necessary.

> one of the only emsam studies I know of. I had an appointment with Dr. Bodkin the study doctor a few months ago and he did recommend the patch to me. He was an amazing person to talk to and no ego. Unfortunately the doctor I have now is the complete opposite but he may give me the emsam when it comes out. Below is the study, the full article is free too:
> Transdermal selegiline in major depression: a double-blind, placebo-controlled, parallel-group study in outpatients.
> Bodkin JA, Amsterdam JD.
> McLean Hospital, 115 Mill St. Belmont, MA 02478, USA. abodkin@mclean.harvard,edu
> OBJECTIVE: The authors investigated the efficacy and safety of transdermal selegiline in adult outpatients with major depressive disorder. METHOD: Following a 1-week placebo lead-in, 177 adult outpatients with major depressive disorder were randomly assigned to receive transdermal selegiline (20 mg applied once daily by means of a 20-cm(2) patch) (N=89) or placebo (N=88) for 6 weeks. The patients followed a tyramine-restricted diet during the medication trial and for 2 weeks after completion of treatment. Response to medication or placebo was measured by using the 17-item and 28-item versions of the Hamilton Depression Rating Scale, the Montgomery-Asberg Depression Rating Scale, and the Clinical Global Impression (CGI) severity and improvement measures. RESULTS: Greater improvement was observed after 6 weeks in patients treated with transdermal selegiline than in those given placebo according to all measures. A statistically significant difference between drug and placebo was seen in Hamilton depression scale and Montgomery-Asberg Depression Rating Scale scores as early as week 1 of treatment. There were no differences in the adverse event profile of the patients given selegiline and those given placebo with the exception of application-site reactions, which were more common with the selegiline transdermal system. No orthostatic hypotensive or hypertensive reactions were observed. CONCLUSIONS: Transdermal selegiline (20 mg applied once daily by means of a 20-cm(2) patch) administered for 6 weeks was an effective and well-tolerated treatment for adult outpatients with major depression. The typical side effects commonly seen with traditional monoamine oxidase inhibitor antidepressants were not observed.




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