Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Tofisopam (Grandaxin) - a Hungarian benzo

Posted by ed_uk on November 14, 2005, at 13:39:26

In reply to Do you think more benzo's will come on the market?, posted by rjlockhart on November 13, 2005, at 15:57:52

Hi everyone,

Tofisopam (Grandaxin), a 2,3-benzodiazepine, is very different to the familiar 1,4-benzodiazepines eg. Klonopin, Ativan, Valium etc. Tofisopam was invented in Hungary.

Tofisopam isn't marketed in the US, it's supposedly quite a popular anti-anxiety drug in Hungary though. Darkhorse tried it, I think he liked it.

R-tofisopam, the R-isomer of tofisopam, is currently being studied as a treatment for anxiety. It might be available in the US at some point in the future.

Tofisopam does not bind to the same receptors as 1,4-benzodiazepines such as Klonopin.

Acta Pharm Hung. 1993 Mar;63(2):91-8.

Excerpts from the clinical-pharmacologic and clinical studies of Grandaxin

Szego J, Somogyi M, Papp E.

EGIS Gyogyszergyar Rt., Budapest.

The authors give a selection from the clinical-pharmacological and clinical studies of Grandaxin (tofizopam), an original Hungarian compound registered in 1976. Tofizopam, a 2,3-benzodiazepine derivative, differs from "classical" 1,4-benzodiazepines not only in chemical structure, but also in pharmacological and clinical-pharmacological properties. It is an anxiolytic without sedative-hypnotic, muscle relaxant and anticonvulsive effects. Tofizopam does not impair psychomotor and intellectual performance, like other benzodiazepines do, in the contrary, it has a mild stimulatory activity. It is potent in alleviating vegetative symptoms accompanying anxiety disorders. Tofizopam has a very low toxicity, mild side effects. The administration of tofizopam does not lead to physical or psychic dependence.





Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:ed_uk thread:578255