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Re: Bz's seem to be very variable from person to perso

Posted by sdb on October 4, 2005, at 18:55:05

In reply to Re: Bz's seem to be very variable from person to perso, posted by blueberry on October 4, 2005, at 16:46:03

Maybe the emergency room doctor only uses diazepam...I think he relates bz's in efficacy of sedation.

Most of the benzos do really the same but there are differences of these substances in liver transformation and especially in one case gastrointestinal absorption.

But there are bz's other than these transforming in the N-Demethyl-Metabolites which targets different locations on benzodiazepinrezeptors.

I think reasons for different actions on individiuals are:

-Does he/she took much bz's or alcohol before
-Differences from person to person of gaba receptors
-Bigger and smaller differences of different receptor binding sites (even alcohol can have different reactions to persons, one can be aggressive the other only sedated taken the same dosage; I personally have zero response of 18mg bromazepam)
-Sedation is probably one property which almost every bz has dosage depended, regardless of substance class

But of course emergency docs dont understand much about chemistry and physiology/biologie of receptors and membranes. They care about other things.

Bye the way a doc told me betablockers would do all the same. But thats absolutely not true, maybe they all lower bloodpressure but there are not big differences (blocking reaction to noradrenaline of nervi cardiaci, catecholamines, ISA, antioxidant properties, selectivity of b1/b2, there are much more b2-rec. on heart tissue than previously believed)

Sorry my long message but I dont like generalized states like that from the emergeny doctor. It's much more complicated.

Thanks for your answer.

kind regards





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