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Re: Keppra (levetiracetam) for bipolar disorder?

Posted by SLS on August 27, 2005, at 9:08:28

In reply to Re: Keppra (levetiracetam) for bipolar disorder?, posted by SLS on August 24, 2005, at 17:57:26

> Keppra had been producing a broad improvement for few days but seems to have stopped working. I am not happy.

I am still not happy.

I'm waiting for this stuff to start working again. I am not optimistic.

I am tempted to add back the Trileptal to rule-out any contribution it may have had to producing my initial antidepressant response to Keppra. Although I had discontinued Trileptal days before beginning Keppra, who knows?

At 1000mg of Keppra, I have experienced almost no side effects. Just a little bit of dizziness in the beginning.

The few studies using Keppra for bipolar disorder targeted 2000mg as a minimum dosage. This is the same dosage most often used for epilepsy, although I have seen dosages of 3000-4000mg used. These higher dosages might actually be associated with a reduced efficacy and carry a higher liability for mental side effects such as irritability, aggression, and psychosis.

- Scott




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