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Re: Keppra (levetiracetam) for bipolar disorder? theo

Posted by SLS on August 26, 2005, at 9:44:13

In reply to Re: Keppra (levetiracetam) for bipolar disorder? SLS, posted by theo on August 25, 2005, at 8:02:09

> > Although it has been associated with the precipitation of mental side effects at a rate of 6%, any exacerbation of your condition would be completely reversible upon the discontinuation of this drug.

> What sort of mental side effects at 6%?

Depression, irritability, aggression, psychosis.

Yesterday afternoon was horrible. Between the hours of 12:00pm - 4:00pm, my depression worsened to a point that I had not experienced in well over a year. It approached my unmedicated baseline. I did recover, but I still have not experienced the improvement I did several days ago. I am still taking 1000mg.

Do dosages over 1000mg provide you with a better antidepressant effect?

How high did you go, and what caused you to discontinue it?

One study that tracked rapid-cyclers noted a few intervening exacerbations between periods of remission. I hope that is what is going on with me.

In a recent NIMH study of levetiracetam, they looked at a couple of dozen bipolar patients. Of course, this isn't many at all. However, none of those who were severely depressed responded to it. Patients were given 2000-3000mg.

Several studies noted that levetiracetam had positive effects on rapid cyclers, including the NIMH study. I was an ultra-rapid cycler for over two years. I can only hope that there is something about my biology that is cyclic that this drug will finally address.

One can hope...

- Scott




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