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Re: Keppra (levetiracetam) for bipolar disorder? SLS

Posted by zeugma on August 18, 2005, at 7:16:39

In reply to Re: Keppra (levetiracetam) for bipolar disorder? zeugma, posted by SLS on August 17, 2005, at 18:46:16

> You might want to begin looking at the way the X and Y clocks are synchronized and see if there is some way to cue or reset them using environmental stimuli like a light box or well-timed melatonin ingestion.>>

Interestingly I was prescribed a light box many years ago after my first sleep study. Let's say 'compliance' was an issue. It was impossible for me to wake up before 2 pm on a consistent basis, much less at 6 am as the sleep doc advised. I used it intermittently over the years and unsurprisingly got no major benefit from it.

I wake up now fairly regularly by 6 am. I could retry it, as the thing takes up half my apartment (!).

<From what I understand, depression can affect adversely the periodicity of hypocretin secretion.

Do you have any thoughts then on why modafinil is not considered an effective AD? I seem to get an AD effect from it, but that could be because it reduces core symptoms of melacholia (agitation and lack of interest in food).

> As far as Zyprexa is concerned, many people on PB have described it as producing or enhancing "clarity" of thought or thinking more clearly. I myself experienced this when I added it to help control an antidepressant-induced mania. I think Zyprexa has a positive influence on executive function in areas that might also contain hypocretin neurons such as PFC.>

yes, that's on the right track. i have serious executive function issues. Notably, these are helped more by provigil than by ritalin, though I do derive some benefit from ritalin.

> For me, Abilify has increased motivation and mental energy. It has also protected me from suicidality by dissipating anxious catastrophic thinking.

It's well worth it then.

> - Scott




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