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Does anyone like typical APs???

Posted by ed_uk on July 31, 2005, at 14:33:24

In reply to Haloperidol (Haldol), posted by ed_uk on July 29, 2005, at 15:57:15

OK, so we all know that lots of people who've taken typical APs have hated them - especially me and Declan!

I was wondering whether anyone actually liked typical APs????????

I know xbunny likes flupenthixol (Depixol) 6mg for schizophrenia. 6mg flupenthixol is 'equivalent' to about 6mg haloperidol.

Jay likes perphenazine (Trilafon) for agitation. I think he takes 4mg prn. 4mg perphenazine is 'equivalent' to about 1mg haloperidol.

Maxime takes 25mg chlorpromazine prn (Thorazine) for agitation. 25mg chlorpromazine is 'equivalent' to about 0.75mg haloperidol.

River1924 finds trifluoperazine (Stelazine) calming. I think he takes a small dose prn.

CareBear found 0.5-1mg haloperidol (Haldol) to be effective for anxiety.

.........all these doses are relatively low. I will continue to believe that typical APs are considerably more useful at small doses than at mega-doses, except perhaps in a few isolated cases. Even in schizophrenia, small doses can be useful. It is my belief that these potent dopamine antagonists should be carefully titrated within the low-dose range, to achieve the optimum efficacy without producing disturbing side effects. Of course, even low doses of typical APs appear to result in a high incidence of TD when used on a long-term basis. In a world where the atypical APs are hyped, it's still important that the typical APs remain available for the (small?) proportion of patients who find them more effective or more tolerable than the atypicals.





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