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Re: Haloperidol (Haldol) med_empowered

Posted by ed_uk on July 30, 2005, at 8:09:24

In reply to Re: Haloperidol (Haldol), posted by med_empowered on July 30, 2005, at 7:12:46

Hi Med,

J Psychopharmacol. 2001 Dec;15(4):251-5.

Determining the optimal dose of haloperidol in first-episode psychosis.

Oosthuizen P, Emsley RA, Turner J, Keyter N.

Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa.

Uncertainty exists as to the most appropriate dose of haloperidol in first-episode psychosis. This study set out to determine whether ultra-low doses of haloperidol could successfully treat patients with first-episode psychosis. Thirty-five patients with a first episode of psychosis were treated with haloperidol in an open label, fixed protocol over a 12-week period with doses restricted to 1 mg per day for the first 4 weeks. Twenty-nine (83%) remained on haloperidol after 12 weeks at a mean dose of 1.78 mg per day, 16 (55%) had stabilized on 1 mg/day or less. The mean percentage reduction in Positive and Negative Symptom Scale score between baseline and 6 and 12 weeks was 30.3% (SD 20.9%) and 41.4% (SD 16.6%), respectively. There were *no* significant differences in mean extrapyramidal symptom ratings between baseline and 12 weeks. Ultra-low doses of haloperidol are effective and well tolerated in first-episode psychosis. ****Initial doses should be maintained for a sufficient period of time to allow for the medication to take full effect.*****





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