Psycho-Babble Medication | about biological treatments | Framed
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Re: info for anybody with working memory problems

Posted by alienatari on April 23, 2005, at 5:27:08

In reply to info for anybody with working memory problems, posted by scatterbrained on April 23, 2005, at 1:28:10

Thats interesting thanks for posting the info. Gosh i wish i would have known that before I started long-term therapy with antipsychotics that have given me TD and well thats probably whats giving me my memory problems that everyone keeps complaining about :(

Dammit, why dont doctors tell us about these risks before we take these damn drugs? arghh!!!!!!

> The following article is a bit old but still important, especially for anybody with working memory problems.
> New Haven, Conn. -- Working memory loss can be reversed using a short-term drug regimen that produces long-lasting effects, a Yale study has found.
> Results from this study led by Stacy Castner at Yale School of Medicine may ultimately lead to new treatment strategies for those who have lost working or short-term memory. The team's past studies suggest that long-term treatment with antipsychotic medications for diseases such as schizophrenia, decrease the number of D1 receptors in cortical neurons. D1 receptors are one of five known dopamine receptors, which control memory function.
> Published in the March 17 issue of Science, results from this new study show that long-term treatment with antipsychotic drugs produces memory impairments when the treatment lasts over several months.
> "We also found that the memory deficits produced by anti-psychotic drugs can be reversed by stimulating D1 receptors with a D1 agonist-a drug that stimulates mainly D1 receptors," said Castner, associate research scientist at Yale School of Medicine.
> The D1 agonist used in the study was ABT-431, an experimental and not yet available drug which effectively reversed memory loss in six primates. The improvements have been sustained for more than a year.
> The return of short-term memory, which is often lost due to age and diseases such as schizophrenia and Parkinson's, is critical because short-term memory allows individuals to briefly hold information in mind while the knowledge is processed to determine an appropriate action.
> It only took a relatively short treatment regimen of 25 days to get a positive effect, and it could be even shorter with the same effect, said Castner. The improvement in memory persisted for months and years after the last treatment, suggesting that the state of the circuitry involved in memory processing had been permanently or semi-permanently restored to a different level of sensitivity.




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