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Nardil maintenance dose not effective IMO djmmm

Posted by Questionmark on January 31, 2005, at 21:19:35

In reply to Re: Interesting info about Nardil, posted by djmmm on January 31, 2005, at 10:12:23

> Since Nardil is considered an "irreversible" MAOI-- meaning it formes a permanent covalent bond to MAO enzymes-- MAO activity is consistant until new MAO is manufactured by the mitochondria of your cells.
> Parnate is not considered completely irreversible, since new MAO is produced more rapidly, due to the cohesivness of the bond Parnate forms with MAO enzymes.
> Nardil is also a hydrazine deravitive. These meds tend to "build up" in your system, often requiring liver function tests (due to potential liver toxicity). Because Nardil is truely "irreversible" and accumulates in your body, taking a "maintenance" dose of as little as 15mg every other day is possible for most people (only after maximum effect is achieved).
> Im not too familiar with "poop-out" and MAOIs. My theory is that "poop-out" is mostly a serotonin issue, excess serotonin to be specific.

In my personal experience with Nardil, the concept of keeping a low maintenence dose after a short "loading" period (usually about four to six weeks i believe) at a higher dose (usu. 60-90mg) does not work at all, despite how it may look on paper. i'm on 60mg/day, and oftentimes if i reduce it to 45mg/day for a few days-- or even 30mg for a day or two-- i notice myself feeling worse... in multiple areas. And if i miss a mere day's worth of Nardil entirely, the following day i end up feeling significant differences in my mood, anxiety levels, and ability to think clearly, for example. i really wish the maintenance-dose theory worked, but i'm certain that it does not for me.
Maybe new MAO enzymes are restored by the body around every 24 hours or less (almost definitely). Maybe phenelzine doesn't really render the MAO enzyme inactive for as long as is believed (doubtful). Maybe the so-called "new" formulation of Nardil is absorbed (and hence, metabolized &/or excreted) much more quickly than the "old" formulation-- so that the "old Nardil" did actually stay in the body long enough for the maintenance-dose-type-theory to hold true, and the "new Nardil" does not stay active in the body long enough for the theory to hold true. Actually, i just thought of some things that don't allow this to make sense, but it doesn't matter. My point is that i don't know, but i do know that i really don't believe the maintenance dose theory could be effective for many people at all, especially or at least on the new Nardil formulation. i would be highly interested to know why this is though (on a pharmacological or pharmakinetic level). Any thoughts?




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