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Re: Nardil and Parnate/GABA bluebird

Posted by King Vultan on October 22, 2004, at 19:47:02

In reply to Re: Nardil and Parnate/GABAKingVultan, posted by bluebird on October 22, 2004, at 17:11:57

> Hello, this is bluebird. How's the 50mg of Parnate going? I went to my doc and she wanted me to stay at 40mg for another 2 weeks. I wanted to go up to 50mg but she says wait. So on to my question for you. If Nardil also affects the GABA and that is so helpful with anxiety (which I have a lot of) is there a med that affects only the GABA that can be added to the Parnate? Just curious. I wanted to try Parnate 1st because of less SE's. Parnate at 40mg for 2 1/2 weeks and 30mg for 2 weeks prior hasn't had the antidepressant affect as of yet. Well, not like I was hoping for that is. My doc says it takes time. She originally wanted me to take Nardil but I chose Parnate. So the GABA is the main difference? I enjoy your info that you provide.
> Thanks for all of the posts it is appreciated. Hope all is going well.
> Thanks, bluebird

There was a significant increase in antidepressant efficacy along with a similar increase in insomnia, which was already terrible, about a week after increasing the dosage. I also did not experience the depression this time that I did going from 20 to 30 and 30 to 40; I just felt a little flat at times in the first week after going up. So I'm really doing pretty good, but I believe I would be doing even better if I got more sleep. I am soon going to give trazodone a try again, as I mentioned in some other post today. I am thinking that Parnate may have corrected the problem (by downregulation of receptors) that caused trazodone to give me depression when I tried it on Nardil.

For GABA effects, you can always add some kind of benzodiazepine. Klonopin/clonazepam seems to be one that is very widely used. Benzos are safe with Parnate, as they are with Nardil. I know there are some issues with long term benzo use, however, as they can cause dependence, and therefore, difficulties when withdrawing from them.





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