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Re: synergism of 5HT2 antagonism + NRI

Posted by jboud24 on October 19, 2004, at 22:42:06

In reply to Re: synergism of 5HT2 antagonism + NRI, posted by zeugma on October 19, 2004, at 19:44:51

That's an interesting article, although I'm left wondering about what the implications are. Perhaps a direct displacement of 5-HT leading to more available 5-HT in the synapse? Perhaps this is giving a kick to the NRI's by adding a second serotonin mediated anti-depressant response. I dunno. I wouldn't read too much into though since humans aren't rats, and the forced swim test is jst one measure of anti-depressant activity.





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