Psycho-Babble Medication | about biological treatments | Framed
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SSRI Theory

Posted by jboud24 on October 14, 2004, at 18:14:53

Hi, I'm new to the PB board, even though I've been reading it for quite some time now.

I have a theory about SSRI meds that I have been struggling with and refining for quite some time now. Basically it's this:
SSRI's inhibit the reuptake pump for the serotonin transporter, this much we all know. This is the way that they increase synaptic 5-HT. But, after a while, wouldn't this prevent the proper level of 5-HT from getting re-packaged into the vesicles and subsequently released?
I have thought that this is a flawed mechanism for a long time know, and have always thought that MAOI's were a better way to go, specifically because they don't screw up the amount of monoamines for repackaging and subsequent synaptic release.
I know this is pretty pharmalogically based, but has anyone else thought about this before? If so, does anyone think this is why MAOI's show such a better success rate?

Justin (100 mg Zoloft currently, and very
disatisfied with SSRI's in general)




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