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placebos, poop-out and Cymbalta karaS

Posted by zeugma on September 30, 2004, at 20:21:09

In reply to Re: Cymbalta and REM sleep - dreaming? ALSO zeugma, posted by karaS on September 28, 2004, at 17:17:47

yes I agree that 20% is quite low. But keep in mind the phenomenon of 'placebo drift' - placebos are getting stronger over the years! No, they're not slipping covert mood-elevators into the sucrose. People with less severe depressions, who would not have been among the populations in which the AD effects of TCA's and MAOI's were first observed, are now routinely included in AD trials. Such people are more likely to have a placebo effect. Can placebos poop out, too? Probably for someone who has a severe depression, but likely not for one who has never been acquianted with the safe confines (I mean in terms of razor-free and carefully monitored) of a psych hospital.

Have you made up your mind to try Cymbalta?

-z


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