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Re: To JRBecker and question on neurogenesis article Denise1904

Posted by jrbecker on September 14, 2004, at 11:14:05

In reply to To JRBecker and question on neurogenesis article, posted by Denise1904 on September 13, 2004, at 15:45:02

> Hi JrBecker,
> I was reading an article you posted a short while ago on the hypothesis that damage to the hippocampus triggers depression and that the stimulation of new nerve cell growth contributes to a patients response to antidepressants.
> What I find so frustrating is that all the studies seem to go by the view that anti-depressants can take a couple of weeks to work if not that then a month or so. When my own experience and I'm sure the experience of others too has proven that not to be the case.
> In the past, Prothiaden worked within a matter of days and Seroxat worked with days too and believe me (I know) it wastn't a placebo affect (no matter what the doctors think) so do you know of any studies where they actually take into account the fact that some people do respond to them very quick, or does any of the scientific community ackowledge that fact (because it is fact)?
> Thanks...Denise

I'm sorry, I don't know of any articles off-hand, but I'm sure they do exist. I would try pub-med if you like to investigate further.
To put it briefly, there are many theories to why the antidepressant response is delayed in most people...1) the time it takes for 5-HT1A receptor to desensitize 2) neurogenesis 3) other theories abound. When most experts talk about a ROBUST early response to a typical SSRI, they usually chalk it up to that individual having possible Bipolar symptomolgy. But I think this is definitely not a full explanation for most early responders. But as an atypical individual/Bipolar II sufferer who does respond early to most antidepressants, I do believe that this theory holds some clout.

In regards to the hippocampal damage theory of depression, I do not believe that it is the end-all explaination to most forms of depression, but rather this damage manifests itself as certain depressive symptoms. Secondly, the notion of neurogenesis as the end-all cure to depression is definitely not plausible. However, it may be a big part of the puzzle.

Depression, Bipolar disorder and many other psychiatric illnesses have many genetic and environmental correlates. In terms of the genetic correlates, there are quite a few genes that thay have already found to be associated with the condition [and they will probably found many more]. So, there is no easy answer about the one "cause" of depression.

As this is a rather complicated issue, it would be best to try to explore this topic by reading the literature yourself.

these sites are a good place to start... [psychiatry -->depression section]

I also could provide you with a few articles if you post your email.





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