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Re: Trouble sleeping - please help King Vultan

Posted by KaraS on September 11, 2004, at 15:47:51

In reply to Re: Trouble sleeping - please help KaraS, posted by King Vultan on September 11, 2004, at 10:07:28

> I'm not actually worried about either Ambien or Halcion anymore, as I decided the hang up I used to have about these types of meds was silly. Why the change? Probably from starting to read message boards like this one. I use Halcion rather than Ambien because Halcion is available as a generic and costs me only $10 for 30 pills, compared to Ambien at $50 for 30 pills. I believe Halcion is also more powerful.

So how have you prevented tolerance to Halcion? Are you only taking it once or twice a week?

Can you tell me more about hydroxyzine and it's use for sleep?

> I only used trazodone for three days while on Nardil, as it made me more and more depressed each day I used it. I now believe this may have something to do with the same issue that caused me to get very sleepy on Provigil--the hypothesis that this may be a result of having hypersensitive dopamine autoreceptors. Since my thought was that the extra dopamine being made available by Provigil was shutting down my dopamine neurons via this mechanism, trazodone could quite possibly do the same thing because one of its major effects is to blockade serotonin 2A receptors, which also releases dopamine. This is also one of the mechanisms by which atypical antipsychotics work--they release dopamine to counteract negative psychotic symptoms by blockading serotonin 2A receptors.

Does the fact that I respond paradoxically to dopaminergics mean that I also have presynaptic hypersensitive dopamine autoreceptors or are there other possible explanations? (BTW, Provigil didn't make me sleepy or alert - just produced that leaden limbs feeling. I may not have tried enough to get more of a reaction though.)

> I found an Australian site yesterday listing the dosage of doxylamine succinate, the stuff in the OTC Unisom tablets, as 25-50 mg for sleep. I believe the maximum recommended in the US is only 25 mg, but I have been having so much trouble sleeping, I did decide to go with 2 x 25. I did sleep drastically better than I did on the 2 x 25 mg Benadryl I had used a couple nights before, but I was a little zonked this morning. I think I will try one Unisom pill next time and see if I can get away with that.
> Todd

I should try the Unisom because it would be a cheap and easy fix but I'm so afraid to. The Benadryl was so awful. I was so exhausted and drugged feeling yet my heart was racing (as I said earlier). It's a horrible state to be in because you can't sleep yet you can't do anything else because you're so drugged feeling. Each minute was like an hour. Wish I could know the result without having to do the experiment.





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