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Re: Blood levels for desipramine? Ame Sans Vie

Posted by Larry Hoover on August 29, 2004, at 8:07:55

In reply to Blood levels for desipramine?, posted by Ame Sans Vie on August 29, 2004, at 7:46:55

> Does anyone know if there is a therapeutic window for desipramine that can be determined by blood level?

The lower bound of therapeutic response to desipramine is 116 ng/ml. The upper bound is not clearly established (i.e. that point at which toxicity effects become significant, vis a vis response).

Do you think you can get tested for desipramine concentration? Way cool, if you can.

> I've been taking 200mg daily for close to three weeks now and possibly experiencing some benefit... at the very least it's given my Adderall more of a punch! No side effects at this dose either, save a very mild orthostatic hypotension that I can easily put up with.

You're a tad impatient. Three weeks is not long enough to judge response. Three months is.

> I'd just like to decide at what point I'm going to consider my desipramine trial a wash and jump on the Cymbalta bandwagon (and/or give selegiline a try at an MAO-B selective dose, along with pharmaceutical beta-phenylethylamine).
> ~Michael

Do you have any idea what your 2D6 status is? Extensive metabolizers only sustain desipramine concentrations below 50 ng/ml.





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