Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Cymbalta, low-dosing - for med-sensitive types

Posted by jrbecker on August 25, 2004, at 10:00:53

In reply to Re: Cymbalta Samples-Question theo, posted by SLS on August 25, 2004, at 7:53:22

This strategy will probably only work for a very small minority of people since most will definitely have to push the dose up to 40-60mg to see beneficial results...but for those that want to be conservative and start low and go slow, here's some reassuring news.

Int Clin Psychopharmacol. 1997 May;12(3):137-40.

An open-label study of duloxetine hydrochloride, a mixed serotonin and noradrenaline reuptake inhibitor, in patients with DSM-III-R major depressive disorder. Lilly Duloxetine Depression Study Group.

Berk M, du Plessis AD, Birkett M, Richardt D.

Department of Psychiatry, University of the Witwatersrand, Johannesburg, South Africa.

Duloxetine hydrochloride, a mixed reuptake inhibitor of serotonin and noradrenaline, was studied in a 6 week open-label uncontrolled multicentre design at a dose of 20 mg daily both in in- and outpatients meeting DSM-III-R criteria for unipolar major depressive disorder. Seventy-nine patients took part in the study. The mean score on the 17-item Hamilton Depression Rating Scale at baseline was 24.9 (SD 4.4), decreasing to 8.5 (SD 7.8) after 6 weeks using a last observation carried forward analysis. Clinical response, defined as a 50% reduction in 17-item Hamilton Depression Rating Scale scores, occurred in 78.2% of patients, whereas remission, defined as a 17-item Hamilton Depression Rating Scale score of < or = 6, occurred in 60.3% of patients. Duloxetine hydrochloride was safe and well tolerated in this patient population.

PMID: 9248869 [PubMed - indexed for MEDLINE]




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:jrbecker thread:378908