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Re: The *Real* Truth - zeugma too zeugma

Posted by SLS on August 25, 2004, at 8:07:54

In reply to Re: The *Real* Truth - zeugma too SLS, posted by zeugma on August 25, 2004, at 7:29:02

I don't know if this will add anything to what you already know, but...


Nortriptyline: increased slightly by methylphenidate 2D6

Nortriptyline: decreased slightly by modafinil 3A

Buspirone: decreased by modafinil 3A

Methylphenidate: increased slightly by nortriptyline 2D6

Modafinil: no change

Clonazepam: decreased by modafanil 3A

Clonazepam active metabolite: increased due to induction on parent compound..... "This therapeutically active metabolite may be increased because the parent compound's metabolism is induced by a cytochrome. The effect is like opening a flood gate leading to an increased level of the metabolized drug. This is especially significant if the metabolite contributes significantly to the therapeutic effect or the metabolite is the active drug and the drug given is not pharmacologically active."


The program was published by a group from Harvard University. I think it is important to note that these interactions are "on paper" and that each and every one has not been determined clinically.

- Scott




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