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Re: The *Real* Truth - zeugma too

Posted by SLS on August 25, 2004, at 7:17:06

In reply to Re: The *Real* Truth - zeugma too Dave001, posted by zeugma on August 25, 2004, at 5:32:44

> Note that modafinil also causes significant induction of the CYP3A4/5 enzymes, and is an inducer of its own metabolism.
>
> Dave
>
> yes i know that. i take buspirone (30 mg) and clonazepam (1 mg) which could be affected by this. i'm not worried about the buspirone because that drug has such a short half life, and its metabolite (which will increase as a result of enzyme induction)is an alpha 2 antagonist which probably has a therapeutic effect for me. the clonazepam is more serious but i was taking Provigil for over a month at dosages up to 100 mg/day and did not notice increases in anxiety.
>
> the problem is that i'm also taking nortriptyline 100 mg/day and that makes 5 meds taken concurrently which could be very complicated. if anything 3A induction would lower nortriptyline levels slightly. but it's the effect of all 5 that concerns me.

Hi Z.

I see that 3A is a minor pathway for nortriptyline metabolism.

Is there a site on the Internet you use to stay current on CYP450 information?

I have an older program that can compare the interactions of multiple medications. If you list them, I can check them for you.


- Scott

 

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