Psycho-Babble Medication | about biological treatments | Framed
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Re: only one rule - *evenually everything poops* linkadge

Posted by Questionmark on June 24, 2004, at 2:50:18

In reply to only one rule - *evenually everything poops*, posted by linkadge on June 23, 2004, at 16:44:53

> I don't know of one person who has not experienced a decline in effectivness in their medications.
> Sure, everyone at the beginning gets that rush, as if they will never be unhappy again but it always fades. It either moves to a complete relapse or just to a steady apathy.

i think you are probably right (unfortunately). But...

> You see the problem is that neurotransmitters are only half the battle. You can jolt them with as much neurotransmitter as you want, but eventually the circutry itself gets tired. Glutamate is the final destination excitory neuotransmitter and if you push that one too hard it gets angry and kills off the neuron (glutamate toxicity).

...i don't agree that glutamate, or glutamate-induced excitotoxicity is the primary factor in medication poop-out. The main reasons, i believe, are almost certainly receptor adaptation, adaptation of neurotransmitter release (and of reuptake and of degrading enzymes such as MAO and COMT), and-- probably even more so, and involving all of the aforementioned factors-- changes in neuronal gene... [i don't know what the correct word is--] (structure? transcription?) (something or rather)... genetic changes in the neurons. i think the only real way to absolutely prevent poop-out would by through genetic engineering or manipulation or something (genetics is way over my head-- obviously). i hope i'm wrong but i don't think so.

> Sorry to seem like such a downer, but its true, even our best antidepressant ECT is notorious for pooping.
> Linkadge

i know, me too.
It's true (about ECT).




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