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Re: wash-out before maoi Sad Panda

Posted by King Vultan on May 30, 2004, at 11:22:41

In reply to Re: wash-out before maoi King Vultan, posted by Sad Panda on May 27, 2004, at 11:46:34

> >
> Hi Todd,
> If one + equals a range of 1000-10000, then I would say that + and ++ are would be clinically insignificant. Do you think you could put up some data for the other TCA's? I am fascinated that clomipramine gets a ++ for D2 blockade & I'd also like to see the comparison of the different TCA's that this book offers.
> Cheers,
> Panda.

Well, it's a little tedious transcribing the receptor info just for one drug, let alone all of them. You may want to consider getting the book yourself, as it has a wealth of information in it. I actually got it because my local Barnes & Noble had it, and I was fascinated by the receptor chart. It is interesting, but bear in mind that it is based on classic studies from the 90's involving rodent tissue. I have other data derived from human cadaver tissue that suggests that the TCAs may be more serotonergic in people than they are in rats or mice. The pharmacology of psychotropic drugs does seem to vary depending on which particular study you are looking at.





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