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Re: GHB(xyrem) vs. ALCOHOL Michael Bell

Posted by btnd on May 29, 2004, at 13:54:48

In reply to Re: GHB(xyrem) vs. ALCOHOL zeugma, posted by Michael Bell on May 28, 2004, at 21:43:09

> >
> Sure, I definitely drink alcohol. Not often, but I consume a lot on the occasions that I do drink. It is extremely prosocial for me, especially when taking Picamilon. However, the prosocial effects are short-lived and tolerance does build up quickly.

I havent tried Picamilon yet (i will definitely some-time soon). But I find Klonopin + 2/3 beers making me more pro-social. But amphetamines+GHB is better.

> Regarding GHB, I believe it is a substance already found in the body. So the question is, if it is so effective for social phobia, could there be a GHB receptor/transmitter disfunction that Xyrem "fixes"?

Yes it is natural. The way GHB works via agonism at GHB receptors (the only anti-depressant that works via this agonism; although Amisulpride (Solian) has some action on it too) and GABA(B), probably GABA action is taking care of anxiety, and GHB receptor-action (which starts the process of building up the levels of dopamine) is making it so pro-social.


> For me, social phobia = social anxiety + reward deficiency. Acute alcohol intake seems to address both aspects.

I agree. But only short-term I believe.


> Benzos take care of the anxiety, but are not prosocial (and even seem to add to anhedonia).


I also agree.


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