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thanks for the info, and another ? King Vultan

Posted by zeugma on May 25, 2004, at 18:46:57

In reply to Re: wash-out before maoi zeugma, posted by King Vultan on May 25, 2004, at 14:21:31

> >
> > What does your book tell you about the receptor blocking affinities of clomipramine? Probably both 5HT-1A and 5HT 2A blockade is therapeutic for me. The great experiment will be to see what 5HT reuptake inhibition does for me, since I have never taken one long enough to determine the nature of its effects. My hope is that the other actions of clomipramine will make the SRI effects tolerable.
> > >
> >
> >
> Clomipramine
> NE reuptake............+++
> 5HT reuptake........+++++
> DA reuptake..............+
> Blockade 5HT1.........+
> Blockade 5HT2.......+++
> Blockade ACh.........+++
> Blockade H1...........+++
> Blockade alpha-1....+++
> Blockade alpha-2......+
> Blockade D2............++
> where each + represents a difference of one order of magnitude for Ki, ranging from
> +++++ represents Ki = 0.1-1.0
> + represents Ki = 1000-10000
> Todd

Thank you for the info. My pdoc said I could swap nortrip for clomip one-to-one. That was a lot of my reason for wanting to try clomip instead of my lex samples in the first place. The TCA depressant/antidepressant combo (monoamine reuptake blockade vs. H1/5HT blockade) is why I think I responded to nortrip, and is the clue I will follow as i experiment with clomipramine.

By the way, do you think clomipramine + stimulant comes as close to an MAOI as is possible without actually taking one? My thought is that it might COMBINE the attributes of Parnate and Nardil. (In this comparison I would also include the GABAergic effects of the clonazepam I also take.)




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