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Re: wash-out before maoi fuji

Posted by King Vultan on May 21, 2004, at 7:26:26

In reply to Re: wash-out before maoi, posted by fuji on May 20, 2004, at 20:13:29

> Thanks for all the replies. Today I was thinking I could substitute something for the first 3 weeks of prozac washout and then have two weeks off of whatever I substituted or then of course I could just bite the bullet and do the five weeks. Is Nardil activating and is that the reason for insomnia?

Nardil is actually somewhat sedating, particularly when compared to the other MAOI, Parnate. I believe the reason for the insomnia is the increase in availability of serotonin and norepinephrine, which can have a negative effect on sleep, at least for some people. I had bad insomnia on the two SSRIs I've tried, Zoloft and Prozac, moderate insomnia on some of the selective norepinephrine reuptake inhibitors I've tried, such as Strattera and desipramine, and terrible insomnia on Effexor, which works on both serotonin and norepinephrine, so the terrible insomnia I've experienced on Nardil is not unexpected.





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