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Re: Nardil + Remeron- chances of hypertensive crises? ace

Posted by Sad Panda on April 24, 2004, at 3:30:26

In reply to Nardil + Remeron- chances of hypertensive crises?, posted by ace on April 24, 2004, at 0:50:20

> Nardil + Remeron sounds good to me...but what are the chances of a HT reaction...
> I think a serotonin syndrome is highly unlikely
> Ace
> Nardil-60
> Zyprexa 10

None really. Remeron blocks H1, 5-HT2A, 5-HT2C, 5-HT3 & Alpha-2 NE receptors. It is such a potent H1 blocker that at roughly 15mg is has totally saturated H1 receptors & is why it is so sedating at low doses. In the 15-30mg range there is 5-HT2A, 5-HT2C & 5-HT3 blockade. Mostly good things except 5-HT2C blockade can stimulate appetite like H1 blockade. 30mg & up starts blocking Alpha-2 NE receptors which is said to be stimulating, but I just find it irritating. I would think that up to 30mg you will be just fine, after that you may want to monitor your blood pressure. I would expect it to slowly creep up, but I can't see any mechanism that would cause a crisis.





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