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Re: off topic... OCD francesco

Posted by rod on March 31, 2004, at 15:56:30

In reply to any sexual side effects from mood stabilizer ?, posted by francesco on March 30, 2004, at 5:54:36

Dear Francesco,

Some things I also wnated to say to you. Your first diagnosis was OCD (right?). And you said you could meet the criteria for overfocused ADD, rigth? I think this definition sounds like OCD accompanied cognitive and attention abnoramlities.
Some mabye interesting thinks, and to further confuse you ;)

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Brain event-related potential correlates of overfocused attention in obsessive-compulsive disorder.

Towey JP, Tenke CE, Bruder GE, Leite P, Friedman D, Liebowitz M, Hollander E.

Department of Biopsychology, New York State Psychiatric Institute, NY 10032.

A hypothesis of overfocused attention in obsessive-compulsive disorder was investigated by measuring auditory event-related potentials (ERPs) during a selective attention task. Unmedicated patients (n = 18) with this disorder showed significantly larger attention-related processing negativity (PN), with earlier onset and longer duration, than did normal controls (n = 15). In the N200 region (160-250 ms), PN was larger in patients with fewer nonspecific neurological soft signs. This task, however, did not yield any group differences in mismatch negativity (N2a) or classical N200 (N2b). P300 amplitudes for attended targets were smaller for patient than normal groups, but the reverse was true for P300 and positive slow wave amplitudes for unattended nontargets. Collectively, these ERP abnormalities suggest a misallocation of cognitive resources. Because of the importance of the frontal lobe in the control of selective attention, PN enhancement in patients with obsessive-compulsive disorder may reflect hyperactivation of this region. This conceptualization is consistent with recent functional neuroimaging findings.

PMID: 7846214 [PubMed - indexed for MEDLINE]
----

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Cognitive dysfunction in obsessive-compulsive disorder.

Okasha A, Rafaat M, Mahallawy N, El Nahas G, El Dawla AS, Sayed M, El Kholi S.

Institute of Psychiatry, Ain Shams University, Egypt.

OBJECTIVE: Assessment of cognitive functions among obsessive-compulsive disorder (OCD) patients would help in understanding the neurobiology and brain areas involved in that disorder. The objective of this work was to study the cognitive dysfunction in OCD patients and to identify its correlation with both the clinical picture and the severity of the disorder. METHOD: Neuropsychological and electrophysiological event-related potentials were tested in 30 OCD patients and compared with 30 normal volunteers of a matched gender, age and education. RESULTS: Results showed a defective visuospatial recognition, which worsens with chronicity, deteriorated set-shifting abilities, overfocused attention to irrelevant stimuli and delayed selective attention to relevant tasks. Mild cases showed better selective attention than severe cases. Obsessive cases had a defective visual memory, while compulsive cases had delayed perception of task relevant stimuli. Mixed cases showed disturbed information-processing both early and late. CONCLUSION: OCD patients have a characteristic pattern of cognitive dysfunction that differs among patients of varied severity, chronicity and symptom type. We suggest a striatofrontoparietal neural pathophysiology. OCD seems to be a heterogeneous disorder, both clinically and pathophysiologically.

PMID: 10782547 [PubMed - indexed for MEDLINE]
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maybe you overthink your AD(H)D vs. OCD diagnosis. I alctually dont know, becasue I am no doc and don't know you very well. But it might be of some help. These things came into my mind recently, and I just want to write them down... sorry to confuse you again =;)

Roland


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