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Re: Tricyclic antidepressants queries irwind

Posted by Chairman_MAO on February 12, 2004, at 22:15:03

In reply to Tricyclic antidepressants queries, posted by irwind on February 12, 2004, at 17:25:37

Tricyclics (except for trimipramine) block the NE reuptake pump with varying potencies, thereby increasing synaptic NE. They also block the a1-adrenergic receptor; the effect of this is that the cholinergic innervation dominates: vasodialation, etc. This is merely a specific antagonistic action at a specific receptor subtype, though; there are many other adrenergic receptors. Antidepressants are thought to work in part by downregulating BETA adrenoreceptors.


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