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Re: Lexapro + Wellbutrin

Posted by Quinn on December 31, 2003, at 10:50:21

In reply to Lexapro + Wellbutrin, posted by Esmarelda on December 31, 2003, at 9:42:51

I've been on Prozac + Wellbutrin for about 6 months. My PDoc has suggested substituting Lexapro for the Prozac because he thinks the Prozac has become less effective over time (I’ve been on Prozac for 15 years) and he thinks the Lex may be more stimulating (I’ve been feeling very fatigued lately).

I know a lot of people add Wellbutrin to their SSRI to try to offset sexual SEs. This may help some people, but the Wellbutrin made my sexual SEs worse. However, this may be specific to Wellbutrin’s interaction with Prozac, as they both affect isoenzyme CYP-2D6, which Lex does not.

My Wellbutrin was added as a substitute for Effexor, which I was on for about 3 months but doing poorly. The Effexor was added as a substitute for Desipramine, which I had been on for a few years before I started the Prozac.




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