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Re: Klonopin for Adderall tolerance?

Posted by Viridis on August 25, 2003, at 14:36:28

In reply to Re: Klonopin for Adderall tolerance? btnd, posted by Larry Hoover on August 25, 2003, at 6:38:55

I agree with Larry -- from what you've described, these are two different processes. Cells such as neurons have an outer membrane that controls inflow and outflow of various substances, such as ions. Then, there are internal cell structures (organelles) that have their own membranes and act, to varying degrees, independently of the rest of the cell.

Mitochondria are involved in conversion of food energy to energy usable by the cell. They're probably the most independent organelles, and are actually descended from bacteria that invaded early cells around a billion years ago. They have a symbiotic relationship with the rest of the cell, but do many things on their own. Mitochondria act as important calcium storage modules, but I'm not sure how release of calcium ions from mitochondria would affect amphetamine-controlled flow of calcium ions across the outer cell membrane.

Of course, there could be a connection; I'd have to see more evidence. A good way to minimize amphetamine tolerance (if you can do this) is to skip the amphetamine for a day or two now and then. I do this with no problems.

Klonopin + Adderall is a good combo (for me) for anxiety, depression, and ADD. The two seem to work synergistically, and others here have had similar experiences. But as far as one reducing tolerance to the other, I'm skeptical.




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