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Re: Klonopin for Adderall tolerance? btnd

Posted by Larry Hoover on August 25, 2003, at 6:38:55

In reply to Klonopin for Adderall tolerance?, posted by btnd on August 25, 2003, at 0:42:46

> Many studies have indicated that amphetamine (Adderall/Dexedrine/Desoxyn) tolerance is prevented by exogenous or endogenous agents that are able to inhibit excess Ca++ influx into the neuron through the gated calcium channels on the neuronal membrane that have NMDA subtype glutamate receptors.
>
> Taken from the last study I've posted on Klonopin (clonazepam) working together with NADH (or actually increases NADH). The conclusion is:
>
> "...We conclude that clonazepam is an effective inhibitor of mitochondrial [Ca2+] efflux in intact cells."
>
> Do you think Klonopin could be used to prevent amphetamine tolerance? Am I right again? :)

Not this time, as I read these bits.

> Take care.

The first scenario is modulated by calcium influx into neurons, i.e. from the intercellur space. The second scenario involves mitochondrial calcium efflux, i.e. into the intracellular fluid.
The former, flow into a cell from outside. The latter, flow out of an organelle, but still in the cell.

Lar

 

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poster:Larry Hoover thread:253534
URL: http://www.dr-bob.org/babble/20030823/msgs/253802.html