Psycho-Babble Medication | about biological treatments | Framed
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Re: Jack Smith

Posted by jrbecker on July 23, 2003, at 11:43:30

In reply to JR Becker, posted by Jack Smith on July 21, 2003, at 17:26:53

> > Yes, NK-1 antagonists work on substance P - and are considered the same thing.

> Do you have any clue when some of these may be available for depression? I understand that the one now available for chemotherapy-induced nausea is priced extremely high and may be giving the company an incentive to hold its approval for depression.

I doubt they have an incentive to hold their drug up any further. Remember, depression sufferers are a much larger population than those undergoing chemo. Getting as many indication approvals as possible spells $$$.

Merck's drug will probably be the first to hit the market, but that won't be until late '04 -- they're still wrapping up phase III. There are many other companies in tow in phase I and II. If this class proves to be lucrative (which is currently anybody's guess), we can expect to see many of these start to enter the market in '05 and '06.

> So, I take it you don't believe the pregabalin hype? Do you think its efficacy will be similar to neurontin given that it seems to be a modified version of neurontin.

Pregabalin will be an improvement on neurontin. Pfizer is smart enough to know what it has or it wouldn't have pushed it this far as Neurontin's successor. And it will make a fair anxiolytic, better than neurontin most likely. However, there will be some side effects involved, much like neurontin's.

>Xanax XR:
> I'd say it's a slight, but significant tweak on the original form. I think if you didn't like xanax in the first place, you probably wouldn't like the xr. One big thing for me is there is no crash that I used to get from regular xanax. It seems a little less sedating and has a more subtle effect. I have not however decided to use it daily yet. I may in the future. Just not sure I want to go down that road yet, though I definitely get a noticable AD effect.

thanks for the info. I think I plan on holding off in trying it for a while.





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