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Re: Anybody try SIBUTRAMINE (Meridia) for depression?

Posted by SLS on July 17, 2003, at 11:49:55

In reply to Re: Anybody try SIBUTRAMINE (Meridia) for depression?, posted by jrbecker on July 17, 2003, at 11:34:46

> However, I do know that Sepracor is in Phase II trials for a sibutramine metabolite for depression, but is currently on hold due to budgetary constraints.

Hi JB.

Thanks for the heads-up. I found the following:

"Sepracor's (R)-sibutramine metabolite is an isomer of an active metabolite of Abbott's MERIDIA®. The (R)-sibutramine metabolite has been shown in preclinical studies to be a potent norepinephrine, dopamine and serotonin reuptake inhibitor. The compound's unique triple mechanism of action may provide a broader spectrum of therapy than other currently marketed antidepressants. Physicians often prescribe various combinations of drugs to achieve similar outcomes, indicating a need for this potential therapeutic synergy."

This sounds great.

"The (R)-sibutramine metabolite development program for refractory depression is on budgetary hold due to resource constraints."

This sounds not-so-great.

Are you aware of any DA reuptake inhibitors in the R&D pipeline? Nomifensine helped a great many people before it was discontinued.

What's your take on the sibutramine controversy? Do you think the FDA will pull the drug from market?

- Scott




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