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Re: Opiates/alcohol burning questions

Posted by Caleb462 on July 3, 2003, at 2:21:15

In reply to Opiates/alcohol burning questions linkadge, posted by Barbara Cat on July 2, 2003, at 14:54:01

> Opiods and wine trigger a jagged hypomania for me. I get loads of energy and focus. I get a stimulating effect from all opiods and a paradoxical reaction to most other drugs, which might be a quirk of my HPA-axis and cortisol dysreguation.
> My question is this. I have fibromyalgia and will take about 10mg oxycodone or hydrocodone infrequently during a bad fibro day. I've also drank wine the same day. I know, I know. No need to lecture me on the dangers of this combo. This is not alot of substances I'm talking about. Just 1 glass of wine 4 hours after taking the opiod. However, the next day after I combine any opiods and wine I am ALWAYS burnt out, wiped out, depressed, jangled, singed.
> What is going on with these substances? What neurochemistry do opiods/alcohol effect? Dopamine production/inhibition leading to endorphin dump and depletion? Almost like a cocaine, amphetamine surge. Reactive hypoglycemia caused by simple carbs leading to adrendal/cortisol stress? I understand how this could be a factor with alcohol, but it's a problem only when combined with opiods. How do they potentiated each other?
> If I just take opiods I get energized and focussed, but if I add that wine I want to clean house and dance all night and then can't fall asleep. Taken separately is usually no problem, but the combo puts me into rev mode and I pay for days.
> Again, I know this is a bad combination but I've been lately noticing these ideosyncracies. It can lift a depression immediately but only temporarily. My wires are getting stripped and I want to know what's going on physically & neurologically. BarbaraCat

The only thing I can really think of is temporary dopamine depletion, caused by the combined dopamine releases from both alcohol and oxycodone.

I'll post more if I think of anything else, come upon anything else.

Also, 10 mg of oxycodone and 1 glass of wine is not a particularly dangerous combo at all. If the doses were higher, then sure.. but that's really nothing to worry about.




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