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Opiates/alcohol burning questions linkadge

Posted by Barbara Cat on July 2, 2003, at 14:54:01

In reply to Are opiates antimanic ???, posted by linkadge on July 1, 2003, at 19:08:02

Opiods and wine trigger a jagged hypomania for me. I get loads of energy and focus. I get a stimulating effect from all opiods and a paradoxical reaction to most other drugs, which might be a quirk of my HPA-axis and cortisol dysreguation.

My question is this. I have fibromyalgia and will take about 10mg oxycodone or hydrocodone infrequently during a bad fibro day. I've also drank wine the same day. I know, I know. No need to lecture me on the dangers of this combo. This is not alot of substances I'm talking about. Just 1 glass of wine 4 hours after taking the opiod. However, the next day after I combine any opiods and wine I am ALWAYS burnt out, wiped out, depressed, jangled, singed.

What is going on with these substances? What neurochemistry do opiods/alcohol effect? Dopamine production/inhibition leading to endorphin dump and depletion? Almost like a cocaine, amphetamine surge. Reactive hypoglycemia caused by simple carbs leading to adrendal/cortisol stress? I understand how this could be a factor with alcohol, but it's a problem only when combined with opiods. How do they potentiated each other?

If I just take opiods I get energized and focussed, but if I add that wine I want to clean house and dance all night and then can't fall asleep. Taken separately is usually no problem, but the combo puts me into rev mode and I pay for days.

Again, I know this is a bad combination but I've been lately noticing these ideosyncracies. It can lift a depression immediately but only temporarily. My wires are getting stripped and I want to know what's going on physically & neurologically. BarbaraCat


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poster:Barbara Cat thread:238575
URL: http://www.dr-bob.org/babble/20030701/msgs/238782.html