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Re: TMGRon Hill colin wallace

Posted by Larry Hoover on June 6, 2003, at 9:54:59

In reply to Re: TMGRon Hill Larry Hoover, posted by colin wallace on June 6, 2003, at 9:22:20

> Hey there Larry,
> Thanks for your input here;your knowledge on this subject(subjective and otherwise)is much appreciated.Actually, I typically set more store by the subjective anecdote;if we can extrapolate something from scientific fact, fine.But that doesn't mean it will work, as we find all too often with antidepressants!!
> If it works, it works,and that's good enough for me.

Scientific knowledge may suggest that certain experiments be conducted. However, the results of the experiment are not dependent on the knowledge base. Quite right.

Our open-label experimental pool has a low population (N=2), but at least we're consistent.

> --------------------------------------->
> >>> All I know (the fact part) is that taking two substances together, each one an activating and potentially irritating substance, produces a mellow synergism of clarity of function and higher fatigue threshold.
> How much do you take Lar?

Totally on a gut-level "need" assessment (not calendar-related), I'd say I use between 5 and 10 mg/week NADH, and I generally take one gram TMG simultaneously.

>Do you think, in the case of NADH, that more would be needed in the acute stage than the long-term ?

That's what we've found, that there seems to be a saturation process occurring. Early on, your body can handle a large amount, but only until you become replete? I'm not certain that's what's happening, and thus the question mark. Anyway, after that, you only need take small amounts to saturate again.

> And how do you think Folic Acid, as another dopamine precursor, would compare to NADH and TMG??

Strictly speaking, folate is not a precursor, though it is prerequisite. Folate, or folic acid, as absorbed from the diet or supplements, is not active. There are a number of different enzymes which transform folate into active molecular structures; there are many such structures, e.g. the various biopterins. In the activated form, the folates will "encourage" the appropriate enzymes to act in transforming e.g. tyrosine into l-dopa. Folate is a co-enzyme.

It is my opinion that supplementation with a B-complex should be assumed, alongside NADH or niacinamide supplementation.

Niacinamide promotes endogenous (within your body) NADH formation, so niacinamide may also serve to "stretch" the period of responsiveness which follows NADH supplementation, thought that would be hard to "prove".

> Thanks again,
> Col.

My pleasure.





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