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Connections between Short Half Lives and Sedation?

Posted by jack smith on April 9, 2003, at 11:08:07

When I tried Paxil, I experienced pretty bad sedation so much so that even though I had a pretty good ad and anxiolytic effect, I quit it after four months. Now, I am on Effexor XR and am experiencing extreme sedation (150mg). Is it possible that shorter half life ssri's cause more sedation than longer half lives. At 150, Effexor acts mainly as an ssri so if I raised it to 225 is it possible that the NE effect will counter sedation?

BTW, I was on celexa which has a longer half life than effexor and paxil and did not experience significant tiredness or sedation. What do people think?




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