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Re: hypercalcemia

Posted by Larry Hoover on April 3, 2003, at 18:26:38

In reply to Re: hypercalcemia, posted by jemma on April 3, 2003, at 15:07:10

> This is interesting to me. I have ndi - nephrogenic diabetes insipidus - which has caused hypercalcuria and high blood phosphate, low sodium, etc. I control it with 25 mg. of hydrochlorthiozide. Because of ndi, I can't take lithium, which causes ndi in many people. So Mitch, your hypercalcemia may have been a result of lithium.

Fascinating that a diuretic controls a disorder of diuresis. Have you ever been advised to use an NSAID? The combination is more effective than the thiazide alone.

> Larry, how does any of this affect my meds? Currently I take 250 mg modafinil and 10 mg selegiline, along with the hydrochlorthiozide and HRT.

None of these should be affected by your kidney disorder. Surely you were dose-titrated with foreknowledge of the NDI, yes?

>I've often wondered if my brain fox came from a lack of vasopressin receptors in my hypothalamus, as well as my kidney.

Were your psychotropic meds prescribed to deal with brain fog, in particular? They seem to be appropriate for that.

As I understand it, the hypothalamus senses solute concentrations directly, and thus mediates vasopressin release, rather than responding to it. Or have I got that mixed up?

> My ndi appears to be genetic, but it's labelled idiopathic for 'who knows?'

Ya. I hear ya. If experts don't know, who does?

>I've had a lot of weird things go wrong, including postcapsular cataracts. I'm 47, and not diabetic.

Well, I hate to say it, but you're of an age where things, idiopathic things, tend to become prominent.

> Feel free to ignore this. But I've come to admire the scope of your knowledge of the brain's and body's chemistry.
> - jemma

I will always be a student. I have an infinite curiosity. Glad to find that suits others, too.





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