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Re: Gepirone update

Posted by jrbecker on March 27, 2003, at 9:48:23

In reply to Re: Gepirone update jrbecker, posted by patc on March 26, 2003, at 22:06:33

3/25/2003

- Methods for treating psychological disorders using bioactive metabolites of gepirone (Assignee -- Fabre-Kramer Pharmaceuticals, Inc.)

Abstract: Bioactive gepirone metabolites, such as 3-OH gepirone -1-piperazinyl]butyl]-2,6- piperidinedione), and their pharmaceutically acceptable salts and hydrates, can be used to alleviate psychological disorders or the symptoms thereof.

U.S. Patents via NewsEdge Corporation : Abstract: Bioactive gepirone metabolites, such as 3-OH gepirone (4,4,-dimethyl-3-hydroxy-1-[4- [4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6- piperidinedione), and their pharmaceutically acceptable salts and hydrates, can be used to alleviate psychological disorders or the symptoms thereof. The use of these compounds provides advantages over other therapeutic azapirones as they possess superior bioavailability, faster onset of action, and more stable plasma levels when administered to a mammal.

Ex Claim Text: A method of alleviating depression or anxiety or symptoms thereof in a mammal comprising administering an effective amount of a gepirone metabolite, or a pharmaceutically acceptable salt or hydrate thereof, to the mammal, wherein the gepirone metabolite is 3-OH gepirone or 3,5-dihydroxy gepirone.

Patent Number: 6534507

Issue Date: 2003 03 18



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URL: http://www.dr-bob.org/babble/20030325/msgs/213411.html