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Re: Straterra

Posted by paulk on February 10, 2003, at 8:50:35

In reply to Re: Straterra, posted by mom2mbcb on February 10, 2003, at 3:48:38

> well I started on only 18 mg. Fianl update. I will not take it this morning. Yesterday i was a mental mess and Slept off and on in a fog most of the day. Felt a bit better by 8:00 p.m up today at 4:00 a.m.

I just started on 10mg/day (at 200lbs) and think it would have been a big mistake to have started on a higher dosage. After the second day I was having sleep problems and felt shaky. If I had started at a higher dosage I would of been a mess.

from the monograph:
"... A fraction of the population (about 7% of Caucasians and 2% of African Americans) are
poor metabolizers (PMs) of CYP2D6 metabolized drugs. These individuals have reduced activity
in this pathway resulting in

10-fold higher AUCs, 5-fold higher peak plasma concentrations,

slower elimination (plasma half-life of about 24 hours) of atomoxetine compared with people
with normal activity [extensive metabolizers (EMs)]..."

Because of the wide difference in bloodlevel, I (I'm not a doc) would suggest anyone starting atomoxetine(Straterra) to think about starting with a very low dosage. I'm puzzled as to why the remmendations aren't different in the monagraph? Perhaps because it is only labled for children that would tend to be higher metabalizers?




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