Posted by paulk on February 10, 2003, at 8:50:35
In reply to Re: Straterra, posted by mom2mbcb on February 10, 2003, at 3:48:38
> well I started on only 18 mg. Fianl update. I will not take it this morning. Yesterday i was a mental mess and Slept off and on in a fog most of the day. Felt a bit better by 8:00 p.m up today at 4:00 a.m.
I just started on 10mg/day (at 200lbs) and think it would have been a big mistake to have started on a higher dosage. After the second day I was having sleep problems and felt shaky. If I had started at a higher dosage I would of been a mess.
from the monograph:
"... A fraction of the population (about 7% of Caucasians and 2% of African Americans) are
poor metabolizers (PMs) of CYP2D6 metabolized drugs. These individuals have reduced activity
in this pathway resulting in10-fold higher AUCs, 5-fold higher peak plasma concentrations,
and
slower elimination (plasma half-life of about 24 hours) of atomoxetine compared with people
with normal activity [extensive metabolizers (EMs)]..."Because of the wide difference in bloodlevel, I (I'm not a doc) would suggest anyone starting atomoxetine(Straterra) to think about starting with a very low dosage. I'm puzzled as to why the remmendations aren't different in the monagraph? Perhaps because it is only labled for children that would tend to be higher metabalizers?
poster:paulk
thread:133458
URL: http://www.dr-bob.org/babble/20030208/msgs/140413.html