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Re: Strattera half life sjb

Posted by not exactly on February 7, 2003, at 13:00:44

In reply to Re: Anybody else sedated on Straterra? Please respond, posted by sjb on February 7, 2003, at 11:49:16

> Does anyone know what that half life is?

short answer: typically 5 hours, but can be as much as 24 hours

long answer, from the official "prescribing information" document:

Human Pharmacokinetics
Atomoxetine is well-absorbed after oral administration and is minimally affected by food. It is eliminated primarily by oxidative metabolism through the cytochrome P450 2D6 (CYP2D6) enzymatic pathway and subsequent glucuronidation. Atomoxetine has a half-life of about 5 hours. A fraction of the population (about 7% of Caucasians and 2% of African Americans) are poor metabolizers (PMs) of CYP2D6 metabolized drugs. These individuals have reduced activity in this pathway resulting in 10-fold higher AUCs, 5-fold higher peak plasma concentrations, and slower elimination (plasma half-life of about 24 hours) of atomoxetine compared with people with normal activity [extensive metabolizers (EMs)]. Drugs that inhibit CYP2D6, such as fluoxetine, paroxetine, and quinidine, cause similar increases in exposure.

[the complete document can be downloaded from http://pi.lilly.com/us/strattera-pi.pdf]

- Bob


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