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Re: SSRI-induced dopamine depletion Larry Hoover

Posted by BrittPark on December 1, 2002, at 12:40:46

In reply to Re: SSRI-induced dopamine depletion, posted by Larry Hoover on December 1, 2002, at 12:09:29

> Could it? Yes, but I'm answering as a scientist. It has a non-zero probability, so it could.
> My opinion? I think people are far too attached to explanations. The facts are that antidepressant effects can diminish over time. Thinking we might know why has no bearing on whether or not antidepressant effects diminish.

As a scientist myself, I think explanations are always desirable. Of course we are (relatively) in the dark about the mechanism of psychopharmaceuticals. It's important that we don't stay that way.
> If having an explanation makes you feel better, so be it. I don't have an explanation, and I seriously doubt that dopamine depletion is the explanation. If that was the case, taking l-dopa would fix the problem, but it doesn't.

Has somebody done a study showing this?






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