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Re: P.S. Selegiline and the Pill jackstraw232

Posted by Rick on October 18, 2002, at 20:02:35

In reply to Re: P.S. Selegiline and the Pill, posted by jackstraw232 on October 18, 2002, at 14:19:28

Jackstraw, it's hardly an "assertion", it's a well-recognized aspect of the drug's pharmacology. It is documented in the manufacturer's official monograph. BTW, if you search on the terms selegiline and methamphetamine in Medline, you'll come up with about 120 abstracts. It's sometimes thought the amphetamines, even though in fairly small amounts, may contribute to selegiline's activating and potentially anxiogenic effects.

Here's a passage from the selegiline monograph at :

Effects resulting from selegiline administration may also be mediated through its metabolites. Two of its three principal metabolites, amphetamine and methamphetamine, have pharmacological actions of their own. they interfere with neuronal uptake and enhance release of several neurotransmitters (e.g., norepinephrine, dopamine, serotonin). However, the extent to which these metabolites contribute to the effects of selegiline are unknown.


> By the way Rick, what evidence do you have for your assertion that one of selegiline's metabolites is methamphetamine? It is awkward that you chose not to cite any evidence for your claim. Please follow up.




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