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re efficacy and s/e » Anyuser

Posted by IsoM on September 27, 2002, at 16:08:33

In reply to Re: What does Aimee say? » IsoM, posted by Anyuser on September 27, 2002, at 14:25:22

One thing stated that's diff from pharmrep's statements is that 20 mg escitalopram (Lexapro) [not 10 mg] is equivalent to 40 mg citalopram (Celexa).
|| from "A single-dose crossover pharmakinetic study comparing racemic citalopram (40 mg) with the S-enantiomer (escitalopram, 20 mg) in healthy male volunteers."
Drews P New Clinical Drug Evaluation Meeting - Phoenix, AZ 2001 May 28-31 ||

She lists a few different studies that compare Lexapro's faster onset of action than imipramine, fluoxetine, & venlafaxine but none that compared it to Celexa even though she mentioned that Lexapro was faster than Celexa. That's one reason I wondered about her affiliation. She states Lexapro is faster than Celexa but the studies don't state that - just the other 3 ADs. The idea that it’s faster is inferred from a study predicted from a rat model only.

It also states that escitalopram is 30-fold more potent than the R-isomer (Celexa).
|| Escitalopram oxalate. Anti-depressant 5-HT reuptake inhibitor.
Sorbera LA, Revel L, Martin L, Castaner J
Drugs Future 2001 26 2 112-120 ||

To be honest, I found nothing in the article that states that Lexapro is more effective than Celexa in an equivalent dose. (1:2 equivalency rate)

It didn’t compare side effects but only said that with escitalopram, nausea was the most common side effect (15%), somnolence (7%), ejaculation disorder (9%), & anxiety (no percentage given). As the percentage of s/e with Celexa seem to vary somewhat depending on what study or journal one looks at, this may be true for Lexapro too.




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