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Re: Antipsychotic with lowest incidence of TD?

Posted by cybercafe on August 23, 2002, at 1:13:11

In reply to Re: Antipsychotic with lowest incidence of TD? cybercafe, posted by Ritch on August 22, 2002, at 23:56:45

>They all just happen to be higher *potency* antipychotics (response/mg-dosage). The lower the potency, it seems, the less adverse effects-EPS-wise (despite a relatively higher dosage of the lower potency agent). This is highly personalized, so take it with a grain of salt.

Okay here is where it gets tricky. Because of serotonin 5HT2A antagonism, atypicals have a lower incidence of EPS. They "hide" what is going on in the striatum (extrapyrimidal motor area). Normally I think a lower potency drug like seroquel/quetipane (dosage around 100 mg) would have lower eps than a higher potency drug like olanzapine/zyprexa, however! Zyprexa has a much higher potency for the 5HT2A receptor, which means it "hides" the EPS symptoms better. So... what i am wondering is... when you stop taking the drug where long term effects on the dopamine system would cause TD, do long term effects on the serotonin system still compensate?
i can't answer this question, because i do not know the mechanism responsible for TD...
that's why i can only go by anecdotal/experimental data

thanks for your input dude ;)




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