Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

nice one Bill L

Posted by pharmrep on August 21, 2002, at 16:48:03

In reply to Dr. Dave - where did you get your info?, posted by Bill L on August 21, 2002, at 15:53:13

> Dr Dave - I have read about the studies on Lexapro but did not see what you claimed to be true. You said that out of a 40mg pill of Celexa, that 20mg is inert. Where did you read that?
>
> I have read that the other isomer is not effective against depression, but I have not read that it is inert.
>
> On the contrary, I have read about 2 different possible actions of the R isomer:
> 1) it may cause side effects
> 2) it may interfere with the S isomer (possibly by competing for binding sites or some other mechanism)
>
> You claimed that the R isomer is inert and that 20 mg of Lexapro is therefore equivalent to 40mg of Celexa. Since your facts go against other stuff that I have read (ie. items 1 and 2 above), can you tell me your sources? Thanks.

** I see a lot more objectivity these days. Did you see the C. Sanchez study done (microdialysis study comparing citalopram (celexa), s-citalopram (lexapro), r-citalopram and placebo?) In this study it was expected that equivalent increases in serotonin levels within the brain would be seen since 4mg of citalopram contains 2mg of s-cit, and 2mg of r-cit; however, s-cit (at 2mg) increased serotonin levels by about 300% as opposed to only about 200% increase in the celexa at 4mg. This finding indicates that the r-cit actually interferes with the ablility of the s-cit to increase serotonin levels in the brain. It is not known why yet, and additional studies are being done.


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:pharmrep thread:109458
URL: http://www.dr-bob.org/babble/20020821/msgs/117282.html