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Re: R-isomers vs L-isomers Bill L

Posted by IsoM on August 21, 2002, at 16:17:25

In reply to Dr. Dave - where did you get your info?, posted by Bill L on August 21, 2002, at 15:53:13

I'd also like to know more about the differences between the two enantiomers of citaprolam.

Enantiomers can be strange objects. Case in point is thalidomide, the anti-nausea medication that was widely prescribed for pregnant women world-wide a few decades ago. It was found that it was the effects of the inert isomer of thalidomide that caused the horrific birth defects in children born to these women. Thalidomide still has potential as a drug in the treatment of rheumatoid arthritis & leprosy, among others. When it was found possible to separate the two isomers in a racemic mix of thalidomide, great hopes were raised for its general use again. But sadly, the pH of the body reverted the single effective isomer back to a racemic mixture in the body with its resultant side effects.

Isomeric chemistry is not always so clear cut & I'd like to pursue more on these two isomers of citaprolam & research being done on the ineffective one.


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