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Re:10 vs 20 Anyuser

Posted by pharmrep on August 20, 2002, at 15:38:52

In reply to Re: Question re dose pharmrep, posted by Anyuser on August 20, 2002, at 14:57:57

Good observation. In week 7 (of 8wk study) 20mg which had showed an edge over 10mg wks 1-6, became = to 10mg. This was due to the tolerabilty of 20 being slighty less than 10, and a few patients dropped out. (this is called last observation carried forward.) All doctors know about this and take LOCF stats in consideration because that is what a real practice is like...if people stop taking their med due to tolerance issues, the "scores" will reflect that. Anyway, to make a long story short(er)...20mg is more effective than 10mg. You can get the full study the FDA had and see for yourself. The graph is clear. (William Burke of Univ. of Nebraska did the study)


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URL: http://www.dr-bob.org/babble/20020814/msgs/117142.html